Chemistry name:   N-(4-{[(2-Amino-1,4,5,6,7,8-hexahydro-5-methyl-4-oxo-(6S)-pteridinyl)methyl]amino}benzoyl)-L-glutamic , calcium salt

Synonyms:  L-5-Methyltetrahydrofolate calcium; Levomefolate calcium

CAS No.: 151533-22-1

EINECS No.: 691-636-3

Chemical formula:  C20H23CaN7O6

Molecular mass:  497.52 g/mol

Definition:

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Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) Health Benefits:

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) belongs to the folate family of vitamins (vitamin B9, folic acid) and is a coenzyme form of folic acid. Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) is the naturally occurring salt-forming methyl derivative form of folic acid. 5-MTHF, also known as levomethylfolate, is the most biologically active and functional form of folic acid and is more easily absorbed than regular folic acid.

■ Source

In the mid to late 20th century, scientists discovered that natural folic acid (e.g.pteroylglutamic acid) must be converted to 5-methyltetrahydrofolate (5-MTHF) in vivo through a multi-step metabolism before it can be absorbed and utilised, a process that relies on the catalysis of methylenetetrahydrofolate reductase (MTHFR). Early attempts to produce tetrahydrofolate (THF) and derivatives from folic acid by reduction (e.g.sodium borohydride), methylation and other reactions resulted in low purity and poor stability of the products. Research has focused on optimising reaction conditions (e.g. buffer pH, antioxidant addition) to improve the yield and purity of the intermediate THF. In 2000, the research team solved the technical bottleneck of simple decomposition of activated folic acid by combining L-5-MTHF with calcium salts to form stable crystals (L-5-methylcalcium tetrahydrofolate) and using the lattice energy to resist oxidative degradation. This technology has enabled the first large-scale production of calcium L-5-methyltetrahydrofolate, taking it from the laboratory to industrial application.

Particularities of Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium):

Product Specifications:

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) is available in the following specification and contents:

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☑ Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) 95%-102% crystalline powder

Product quality standards:

● ChP/BP/EP/USP/IP/FCC/ISSFA

Production technology description:

●Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) was chemically synthesised by mixing folic acid, a reducing agent, a catalyst and an alkaline solvent in a reduction reaction to produce (R,S)-6-tetrahydrofolate. (R,S)-6-tetrahydrofolate was prepared by mixing (R,S)-6-tetrahydrofolate with p-toluenesulphonic acid and an antioxidant, and chiral cleavage was performed to produce p-toluenesulphonate of 6(S)-tetrahydrofolate. L-5-methyltetrahydrofolate was prepared by mixing 6(S)-tetrahydrofolate p-toluenesulfonate with a methylation reagent and an alkaline solvent for a methylation reaction followed by a ring-opening reaction. L-5-methyltetrahydrofolate was reacted with calcium salt to give L-5-methyltetrahydrofolate calcium.

▶ Promotes nucleic acid production

▶ Prevents fetal neural tube defects

▶ Promotes blood cell development

▶ Food field

▶ Pharmaceutical field

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) is used in scenarios such as megaloblastic anaemia and increased folate requirements during pregnancy, where direct supplementation with active folate bypasses the metabolic barrier of the MTHFR enzyme; as an adjunct treatment for hyperhomocysteinemia, cardiovascular disease and depression, where it reduces disease risk by modulating the methylation cycle; and for the prevention of neural tube malformations (e.g. spina bifida) and recurrent miscarriages. Common dosage forms include tablets, capsules and lyophilised powder for injection.

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) Applications:

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) as a direct source of active folic acid (vitamin B9), is added to infant formulas, maternal supplements and functional foods to prevent folic acid deficiency and to support fetal neural tube development and erythropoiesis. In the elderly population or patients with metabolic disorders (e.g. those with MTHFR gene mutations), folic acid supplementation in a highly bioavailable form reduces homocysteine levels and helps prevent cardiovascular disease and cognitive dysfunction. Common product dosage forms include tablets, capsules or granules, often combined with vitamin B12 and iron to enhance synergistic effects, or added to oral liquids or functional drinks using microencapsulation technology to improve stability.

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) can play the role of a one-carbon unit transporter, participate in the body's nucleic acid and amino acid metabolism, and promote new cell regeneration.

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) is an important element required for fetal neural tube development, and deficiency can increase the incidence of fetal neural tube malformations.

Nutrivitas®Vitamin B9 (Folate (6S)-5-Methyltetrahydrofolate Calcium) is involved in the metabolism of red blood cells in the blood, it can promote the development and maturation of blood cells, if deficient it will easily cause megaloblastic anaemia.

■ Folic Acid VS Folate (6S)-5-Methyltetrahydrofolate Calcium

Folic acid is synthesised from chemical raw materials, not in its natural form, and must be converted by the liver into 5-methyltetrahydrofolate (active form) before it can be utilised by the body. Calcium L-5-methyltetrahydrofolate is a crystalline stabilised active form of folic acid that can be directly absorbed and utilised by the human body without metabolic conversion. It can be directly absorbed and utilised by the human body without metabolic conversion. The absorption rate of folic acid is low and depends on intestinal absorption and hepatic metabolism, which is affected by mutations in the MTHFR gene. Calcium L-5-methyltetrahydrofolate enters the bloodstream directly in its active form and is 12-15 times more bioavailable than regular folic acid.