Chemistry name:  (3R,6R,3′R)-β,ε-Carotene-3,3′-diol

Synonyms:  Xanthophyll; trans-Lutein; Luteine

CAS No.: 127-40-2

EINECS No.: 204-840-0

Chemical formula:  C40H56O2

Molecular mass:  568.871 g/mol

Definition:

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Nutrivitas®Lutein Health Benefits:

Broadly speaking, lutein refers to the lutein class of carotenoids (xanthophy II carotenoids), which includes lutein and its isomers, zeaxanthin and meso-zeaxanthin. Although they have different names, they all essentially belong to the lutein class (xanthophyll II) and can be converted into each other to a certain extent. Nutrivitas®Lutein, also known as marigold extract, is one of the most important nutrients for the human retina and a promising star in the field of botanicals.

■ Source

Lutein was first isolated from carrots in 1831 by the German chemist H.W.F. Wackenroder and named carotene. Later, in 1868, the Austrian chemist Adolf Lieben isolated lutein from the luteum of air-dried cow's ovaries and named it "lutein". 1912, Swiss chemist Richard Willstätter and his assistant Walter Mieg. In 1912, the Swiss chemist Richard Willstätter and his assistant Walter Mieg isolated a single crystal of lutein from egg yolk and determined its exact molecular formula for the first time, a discovery that laid the foundation for the study of lutein. Research into the chemical extraction and application of lutein also progressed. In 1931, the Austrian chemist Richard Kuhn isolated lutein monomer crystals from egg yolk and determined their relative molecular mass.

Nutrivitas®Lutein is one of the photosynthetic pigments found naturally in vegetables (such as spinach, collard greens, green cauliflower, etc.), flowers, fruits and other plants, and can transfer absorbed light energy to the special state of chlorophyll A for its conversion of light energy, which has the role of protecting chlorophyll.

Particularities of Nutrivitas®Lutein:

Product Specifications:

Nutrivitas®Lutein is available in the following specification and contents:

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☑ Nutrivitas®Lutein 75% crystal

Product quality standards:

● USP/FDA-GRAS/Novel Food/GB 1886.382/In-house

Production technology description:

●The main industrial source of natural lutein is the extraction and saponification of lutein esters from marigolds to obtain lutein monomers.The production of luteolin is centred on the fermentation and extraction of marigold through solvent extraction, ultrasonic assisted extraction, saponification and deodorisation, supercritical CO2 purification and other key steps to achieve a high purity preparation.

▶ Eye health

▶ Prevention of obesity-related diseases

▶ Cardiovascular health

▶ Food field

▶ Pharmaceutical field

Nutrivitas®Lutein may be used as an adjunctive therapeutic agent in age-related macular degeneration, cataracts and other diseases, and may slow the development of atherosclerosis through antioxidant activity. The main dosage forms are oral tablets/capsules and eye drops.

Nutrivitas®Lutein Applications:

Nutrivitas®Lutein is widely used as a food colouring due to its bright yellow colour and good stability, suitable for use in a variety of food processing environments. These include prepared milks, frozen drinks, jams, confectionery, convenience rice and noodle products, baked goods, beverages, jellies, etc. Nutrivitas®Lutein is added to foods to improve their nutritional value, particularly in terms of vision protection and antioxidants. It is widely used in infant formulas, formulas for older infants and toddlers, formulas for special medical purposes, prepared milk powders (milk powders for children only), prepared milk (for children only), etc.

Nutrivitas®Lutein is the main carotenoid in the macula of the retina, which can filter some of the blue light entering the retina of the human eye, effectively reducing visual damage, while inhibiting the activity of oxygen free radicals and preventing oxygen free radical damage to visual cells. Lutein supplementation may improve visual function in patients with age-related macular degeneration (AMD) and in healthy individuals.

Nutrivitas®Lutein inhibits the proliferation and differentiation of preadipocytes, which has a lipid-lowering effect. Specifically, it inhibits the activity of peroxisome proliferator-activated receptor-γ (PPARγ), a transcription factor responsible for adipocyte activation, which can downregulate the expression of inflammatory factors such as TNF-α, LP and interleukin-6 (IL-6) and induce the expression of adiponectin, which can then regulate insulin sensitivity, intervene in adipocyte differentiation and play a role in lipid reduction.

Nutrivitas®Lutein has good antioxidant capacity and can effectively inhibit oxidative stress in the atherosclerotic process, thereby reducing the inflammatory response and reducing oxidative damage to tissue cells. High levels of lutein in the blood and fat have been associated with a reduced risk of cardiovascular disease.

■ Structural properties

Nutrivitas®Lutein is a long chain of 40 carbon atoms with alternating single and double bonds on the main chain, forming a polyene chain with nine conjugated double bonds and modified by four methyl groups. Nutrivitas®Lutein has a chromophore in its molecular structure, with a unique absorption peak in the UV-visible region, giving its solution a brilliant yellow colour under visible light. In the human body, lutein is mainly found in cell membranes or lipophilic tissues (such as adipose tissue). The highly unsaturated nature of its molecular structure makes free lutein extremely unstable to light, heat and oxygen, which readily promote lutein degradation.

In addition, lutein has light-absorbing properties, where a conjugated polyene chain of carotenoids have light-absorbing properties, can be filtered by absorbing high energy blue light (400-460 nm), and can make other wavelengths of light through lutein's maximum absorption peak of 445 nm.

▶ Slows UV-induced skin damage

Nutrivitas®Lutein has antioxidant and lipoxygenase inhibiting properties that can reduce erythema, skin ageing, burns and even skin cancer caused by UV radiation to the skin.

▶ Anti-cancer potential

Nutrivitas®Lutein belongs to the carotenoids, has special physiological activity, can inhibit the growth of human tumours, can resist a variety of cancers such as skin cancer, breast cancer, colon cancer and so on.

▶ Feed field

Nutrivitas®Lutein can promote growth in fish and shrimp, increase disease resistance, improve yolk colour (e.g. egg colour) and improve animal health.

☑ Nutrivitas®Lutein 80% crystal

☑ Nutrivitas®Lutein 10% oil suspension

☑ Nutrivitas®Lutein 90% crystal

☑ Nutrivitas®Lutein 20% oil suspension

▶ Cosmetic field

Nutrivitas®Lutein can be added to face and eye creams for its free radical scavenging, UV damage reduction, antioxidant and anti-aging properties. Nutrivitas®Lutein can also be used as a natural colourant in lipsticks, blushes and other make-up to provide a safe yellow tint.