Definition:

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OmniMixer®Nucleotides premix Health Benefits:

OmniMixer®Nucleotides premix is a homogenized product made by mixing various nucleotides, such as adenosine monophosphate (AMP), guanosine monophosphate (GMP), cytidine monophosphate (CMP), and uridine monophosphate (UMP), with carriers, stabilizers, dispersants, and other excipients in specific proportions. It is widely used in infant formula, functional beverages, health foods, and other products, serving functions such as nutritional fortification, flavor adjustment, and intestinal health promotion. The production of OmniMixer®Nucleotides premix involves multiple critical stages, each of which requires specific technologies to ensure product quality and functionality.

The raw material stage of OmniMixer®Nucleotides premix is the foundation for ensuring product safety, efficacy, and stability in subsequent processing, involving a series of key technologies related to supplier management, raw material selection, testing, and pre-processing.

Raw material control for OmniMixer®Nucleotides premix:

Product Specifications:

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Product quality standards:

● Food grade, Infant formula, In-house，Feed grade

▶ Digestive system health

OmniMixer®Nucleotides premix Applications:

OmniMixer®Nucleotides premix is essential for the growth and repair of intestinal mucosal cells. These cells have active metabolism and rapid turnover rates. Taking a nucleotide supplement can accelerate the repair of damaged mucosa, enhance the integrity of the intestinal barrier, and reduce toxin invasion caused by increased intestinal permeability. Nucleotides are naturally present in breast milk. Studies suggest that adding nucleotides to infant formula reduces the incidence of diarrhea, particularly against rotavirus-induced intestinal infectifons. They provide nutritional substrates for beneficial gut bacteria, such as bifidobacteria and lactobacilli, promoting their growth while inhibiting the overgrowth of harmful bacteria, such as E. coli. This helps maintain gut microbial balance and improve digestive absorption efficiency.

■ Supplier onboarding and dynamic management

Richtek integrates supplier lifecycle information through a digital system, standardizing and streamlining the qualification review and file management processes. Our supplier management system centrally stores qualification documents, historical cooperation records, production capacity data, and more. Permission management enables cross-departmental sharing among purchasing, quality inspection, and production. We ensure full traceability of raw materials from supplier production to enterprise receipt using technical means, with the core principles being data immutability and process transparency. Through data modeling and analysis, we scientifically evaluate supplier quality stability and reliability of cooperation, providing a basis for supplier grading and optimization.

OmniMixer®Nucleotides premix is available in the following specification and contents, customized according to requirements:

☑  OmniMixer®Nucleotides premix

The core application of OmniMixer®Nucleotides premix is as breast milk-like nutritional supplements added to infant formula, rice cereal, and complementary foods. Breast milk naturally contains nucleotides, and premixes can mimic the composition of breast milk to meet the rapid growth and development needs of infants and young children for nucleotides.

Develop functional products tailored to individuals with weakened immune systems, gastrointestinal dysfunction, or those in post-surgical recovery. OmniMixer®Nucleotides premix can be incorporated into solid beverages, such as protein powders and probiotic supplements, and blended with proteins, dietary fibers, and other ingredients to enhance intestinal absorption efficiency. As a single ingredient or part of a composite nutrient in supplements, such as capsules or tablets, premixes rapidly replenish nucleotides to support immune cell proliferation and tissue repair. They can also be used in special medical formula foods (FSMP) to provide nucleotide support for cancer patients, critically ill patients, and others with high metabolic demands. This reduces the body's own protein breakdown.

■ Raw material receiving inspection

Nucleotide purity and structural identification techniques: High-performance liquid chromatography (HPLC) is used to determine the purity of nucleotide monomers (AMP, GMP, CMP, UMP, etc.), ensuring they do not impair functionality or introduce toxicity. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) is employed for precise molecular structural identification of nucleotides, verifying the authenticity of raw materials and eliminating counterfeit or structurally similar impurities.

Safety indicator testing technology: Atomic absorption spectroscopy (AAS) or inductively coupled plasma mass spectrometry (ICP-MS) is used to detect the content of heavy metals such as lead, arsenic, mercury, and cadmium. Additionally, testing is conducted for microorganisms, solvent residues, and contaminants.

Customized formulation capabilities for OmniMixer®Nucleotides premix:

The formulation design of OmniMixer®Nucleotides premix is a critical link between raw material characteristics and end-use applications, requiring a balance between nutritional functionality, physical and chemical stability, application scenario adaptability, and safety. This involves multiple technical approaches to achieve precise formulation ratios, synergistic effects, and quality control.

■ Anti-caking and flowability optimization technology

Richtek uses food-grade anti-caking agents, such as silica, tricalcium phosphate, and magnesium stearate, to reduce particle adhesion. These agents typically have a particle size of 1-5 μm, forming a "spacer layer" with nucleic acid particles. They also undergo surface modification, such as hydrophobic treatment, which enhances water repellency. Fluid bed granulation or dry granulation processes fine powders, reducing their specific surface area and lowering their hygroscopicity. Nucleotides are highly hygroscopic, so moisture absorption can cause agglomeration of particles, reduced solubility, and accelerated chemical degradation. Vacuum or freeze drying is employed to control the moisture activity (aw) of the premix to aw ≤0.3.

The activation and proliferation of immune cells, such as lymphocytes, macrophages, and neutrophils, requires large amounts of nucleotides. When the body experiences immune stress, the synthesis of endogenous nucleotides may be insufficient. Exogenous supplementation can quickly meet the demand and enhance the phagocytic capacity, cytokine secretion, and antibody synthesis of immune cells. In infants and young animals, nucleotides promote the development of immune organs, such as the thymus and spleen, thereby maturing the immune system.

▶ Immune health

■ Nutritional requirements and function-targeted design technology

The primary objective of formulation design is to meet the specific nutritional and functional requirements of certain foods. For example, infant formula requires developmental support, while sports nutrition products require recovery promotion. These requirements necessitate the use of technical methods to determine the types, ratios, and addition levels of nucleotides.

Richtek integrates national and international food additive standards (e.g., China GB 14880, EU EFSA, and US FDA) regarding the scope of nucleoside use and maximum allowable levels to create a database of compliance. Use formulation design software (e.g., SAP Recipe Development) to automatically verify that the total nucleoside content and types of nucleosides (e.g., AMP, GMP, and IMP) in the formulation comply with the standards of the target food product, thereby avoiding excessive or noncompliant additions.

■ Antioxidant and pH buffering system construction technology

For nucleotides that are susceptible to oxidation, such as AMP containing an adenine ring that can be easily attacked by free radicals, natural antioxidants are added at a concentration of 0.02%-0.1%. Examples of these antioxidants include tea polyphenols and vitamin C palmitate. Nucleotides are prone to hydrolysis under acidic (pH <5) or alkaline (pH >8) conditions. Buffer salts (e.g., sodium dihydrogen phosphate and sodium hydrogen phosphate) are added at a concentration of 0.5%-1% to stabilize the premix's pH between 6.0 and 7.0, the most stable range. pH meters are used for online monitoring to ensure the buffering effect.

■ Microencapsulation and barrier technology

Microencapsulation is used to form a physical barrier that isolates oxygen, moisture, and light for easily degradable nucleotides, such as 5'-cytidine monophosphate (CMP) and 5'-uridine monophosphate (UMP). Microcapsules are prepared using a combination of drying and composite aggregation encapsulation methods. The nucleotide retention rate after accelerated testing is detected using high-performance liquid chromatography (HPLC).

High-precision mixing technology for OmniMixer®Nucleotides premix:

The mixing stage of OmniMixer®Nucleotides premix is critical to ensuring product uniformity, stability, and functionality. A variety of techniques are employed to thoroughly mix nucleotides with other excipients, such as carriers and stabilizers, while preventing the loss of active ingredients.

■ Mixing equipment selection technology

Richtek selects the appropriate mixing equipment based on the characteristics of the premix, such as particle size, density, and flowability. The primary objective is to achieve efficient mixing and low residue.

Double-screw conical mixers are ideal for small- to medium-sized batches. Their screw blades rotate to move the material up and down and cross-mix it, making them ideal for mixing nucleotides with lightweight carriers, such as starch or lactose. These mixers achieve high mixing uniformity, with a coefficient of variation (CV) typically ≤5%. Horizontal screw ribbon mixers are suitable for large-scale production. The forward and reverse rotation of the screw ribbons promotes the material's axial and radial flow, reducing stratification. These mixers are particularly suitable for blending materials with significant density differences (e.g., nucleotides and minerals). V-type mixers use the separation and convergence of materials within the container for mixing. These mixers are ideal for blending powdered nucleotides and excipients of similar particle sizes, resulting in minimal residual levels.

■ Mixing process parameter control technology

By precisely controlling process parameters, we ensure stable mixing results. The optimal mixing time is set based on material characteristics (typically 5–30 minutes) to avoid over-mixing, which can cause layering or damage to active ingredients (e.g., nucleotides may degrade under prolonged high-temperature friction). Control the material filling rate in the mixing equipment (generally 30%-70%). Too low a rate may reduce mixing efficiency, while too high a rate may prevent adequate contact due to material crowding. Adjust the rotational speed based on equipment type and material density to balance mixing intensity and energy consumption, avoiding heat generated by high-speed rotation that could affect nucleotide stability.

■ Research on raw material compatibility and synergistic effects

OmniMixer®Nucleotides premix typically contains multiple nucleotides, such as 5'-adenosine monophosphate (AMP) and 5'-guanosine monophosphate (GMP), as well as excipients, which are carriers and stabilizers. Technical measures are required to prevent adverse interactions between components while enhancing synergistic effects.

Richtek uses molecular docking and molecular dynamics simulation techniques to predict interactions between nucleotides and excipients, as well as between different nucleotides. This approach helps avoid "antagonistic effects" (e.g., two specific nucleotides accelerating degradation when coexisting) and identify synergistic combinations (e.g., co-administering AMP and UMP enhances intestinal absorption efficiency).

Stabilisation technology for OmniMixer®Nucleotides premix:

The product stabilization stage of OmniMixer®Nucleotides premix involves the use of technical methods to prevent deterioration of the physical state (e.g., caking and stratification), chemical degradation (e.g., oxidation and hydrolysis), and microbial contamination during storage, transportation, and prior to use. This ensures the stability of the active ingredients (nucleotides) over the long term.

Nucleotides, such as ATP and GTP, serve as the “molecular currency” for cellular energy transfer. They directly participate in the metabolic processes of carbohydrates, fats, and proteins, providing energy for cellular activities. For instance, the energy released by ATP hydrolysis powers physiological processes like muscle contraction and nerve conduction. Nucleotides are the basic building blocks of DNA and RNA and participate in transmitting genetic information and synthesizing proteins. During growth stages, such as infancy and adolescence, or during periods of tissue repair, supplementing with nucleotides can accelerate cell division and tissue regeneration.

▶ Participation in energy metabolism and material synthesis